Non synonymous SNP analysis programs

Natural

Variant

nsSNP

Analyzer

PhD-SNP

Pmut

Polyphen-2

Sift

SNAP

SNPs&GO

TANGO Aggregation Tendency

WALTZ Amyloid Propensity

LIMBO Chaperone Binding Tendency

FoldX Protein Stability

S10I

(S-15I)

Unknown

Neutral

Neutral

Benign

Tolerated

Non-neutral

Disease

Not Affected

Not Affected

Not Affected

 Unknown

A16V

(A-9V)

Unknown

Neutral

Pathological

Benign

Tolerated

Neutral

Neutral

Not Affected

Not Affected

Not Affected

Unknown

E66V

(E42V)

Disease

Disease

Neutral

Possibly damaging

Tolerated

Neutral

Neutral

Not Affected

Not Affected

Not Affected

Slightly Enhanced

G76R

(G52R)

Disease

Neutral

Pathological

Benign

Tolerated

Non-neutral

Disease

Not Affected

Not Affected

Not Affected

Reduced

I82T

(I58T)

Neutral

Neutral

Neutral

Benign

Affect Protein Function

Non-neutral

Disease

Not Affected

Not Affected

Decreased

Not Affected

R156W

(R132W)

Neutral

Disease

Pathological

Benign

Affect Protein Function

Neutral

Disease

Not Affected

Not Affected

Not Affected

Slyghtly Reduced