Substitution at pos 4 from A to V is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.00 Sequences represented at this position:238

Substitution at pos 4 from A to T is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.00 Sequences represented at this position:238

 Substitution at pos 4 from A to S is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.03 Sequences represented at this position:208

Substitution at pos 5 from V to L is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.03 Sequences represented at this position:211

Substitution at pos 6 from C to G is predicted to AFFECT PROTEIN FUNCTION with a score of 0.02. Median sequence conservation: 3.00 Sequences represented at this position:240 

Substitution at pos 6 from C to F is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.00 Sequences represented at this position:240

Substitution at pos 6 from C to S is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.03 Sequences represented at this position:213

Substitution at pos 7 from V to E is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.03 Sequences represented at this position:213  

Substitution at pos 8 from L to Q is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 2.99 Sequences represented at this position:243

Substitution at pos 8 from L to V is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.03 Sequences represented at this position:217  

Substitution at pos 10 from G to V is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 2.99 Sequences represented at this position:242

Substitution at pos 10 from G to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.11 Sequences represented at this position:217

Substitution at pos 12 from G to R is predicted to be TOLERATED with a score of 0.10. Median sequence conservation: 3.09 Sequences represented at this position:204

Substitution at pos 14 from V to M is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 14 from V to G is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.09 Sequences represented at this position:222

Substitution at pos 16 from G to A is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 16 from G to S is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:230

Substitution at pos 19 from N to S is predicted to be TOLERATED with a score of 0.40. Median sequence conservation: 3.05 Sequences represented at this position:230

Substitution at pos 20 from F to C is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:230

 Substitution at pos 21 from E to K is predicted to be TOLERATED with a score of 0.47. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 21 from E to G is predicted to be TOLERATED with a score of 0.16. Median sequence conservation: 3.06 Sequences represented at this position:229

Substitution at pos 22 from Q to L is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.00 Sequences represented at this position:246

 Substitution at pos 22 from Q to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:229

Substitution at pos 29 from V to A is predicted to be TOLERATED with a score of 0.06. Median sequence conservation: 3.06 Sequences represented at this position:231  

Substitution at pos 37 from G to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231  

Substitution at pos 38 from L to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249  

Substitution at pos 38 from L to V is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231  

Substitution at pos 41 from G to S is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 41 from G to D is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 43 from H to R is predicted to be TOLERATED with a score of 0.18. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 45 from F to C is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 46 from H to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 47 from V to F is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 47 from V to A is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 48 from H to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 48 from H to Q is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 49 from E to K is predicted to be TOLERATED with a score of 0.07. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 54 from T to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 59 from S to I is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 61 from G to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 65 from N to S is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 66 from P to A is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 66 from P to S is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 67 from L to R is predicted to be TOLERATED with a score of 0.33. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 72 from G to S is predicted to AFFECT PROTEIN FUNCTION with a score of 0.02. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 72 from G to C is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 76 from D to V is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 76 from D to Y is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 80 from H to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 80 from H to A is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 84 from L to F is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 84 from L to V is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 85 from G to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 85 from G to S is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:227

Substitution at pos 86 from N to S is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 86 from N to D is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 86 from N to K is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 86 from N to I is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:227

Substitution at pos 87 from V to M is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 87 from V to A is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:227

Substitution at pos 89 from A to T is predicted to be TOLERATED with a score of 0.20. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 89 from A to V is predicted to be TOLERATED with a score of 0.21. Median sequence conservation: 3.05 Sequences represented at this position:227  

Substitution at pos 90 from D to V is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.02 Sequences represented at this position:246

Substitution at pos 90 from D to A is predicted to be TOLERATED with a score of 0.07. Median sequence conservation: 3.04 Sequences represented at this position:225

Substitution at pos 93 from G to V is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 93 from G to A is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 93 from G to C is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 93 from G to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 93 from G to D is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 93 from G to S is predicted to AFFECT PROTEIN FUNCTION with a score of 0.02. Median sequence conservation: 3.05 Sequences represented at this position:230

Substitution at pos 95 from A to V is predicted to be TOLERATED with a score of 0.09. Median sequence conservation: 3.01 Sequences represented at this position:249  

Substitution at pos 95 from A to T is predicted to be TOLERATED with a score of 0.09. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 95 from A to G is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.05 Sequences represented at this position:230

Substitution at pos 96 from D to V is predicted to be TOLERATED with a score of 0.21. Median sequence conservation: 3.02 Sequences represented at this position:247

Substitution at pos 96 from D to N is predicted to be TOLERATED with a score of 0.46. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 97 from V to M is predicted to be TOLERATED with a score of 0.09. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 97 from V to L is predicted to be TOLERATED with a score of 0.27. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 99 from I to V is predicted to be TOLERATED with a score of 0.08. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 100 from E to G is predicted to be TOLERATED with a score of 0.10. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 100 from E to K is predicted to be TOLERATED with a score of 0.70. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 101 from D to G is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 101 from D to N is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 101 from D to Y is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 101 from D to H is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 104 from I to F is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 105 from S to L is predicted to be TOLERATED with a score of 0.09. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 106 from L to V is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 106 from L to F is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 108 from G to V is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 111 from C to Y is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 112 from I to T is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 112 from I to M is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 113 from I to T is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 113 from I to F is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 114 from G to A is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 115 from R to G is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 117 from L to V is predicted to be TOLERATED with a score of 1.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 118 from V to L is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 124 from D to V is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 124 from D to G is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 125 from D to H is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 126 from L to S is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.06 Sequences represented at this position:231

Substitution at pos 127 from G to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:230

Substitution at pos 133 from E to V is predicted to AFFECT PROTEIN FUNCTION with a score of 0.04. Median sequence conservation: 3.05 Sequences represented at this position:230

Substitution at pos 134 from S to N is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:230

Substitution at pos 137 from T to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:230

Substitution at pos 138 from G to E is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:230

Substitution at pos 139 from N to H is predicted to AFFECT PROTEIN FUNCTION with a score of 0.04. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 139 from N to K is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 139 from N to D is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.05 Sequences represented at this position:230

Substitution at pos 140 from A to G is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:230

Substitution at pos 141 from G to E is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:230

Substitution at pos 144 from L to F is predicted to be TOLERATED with a score of 0.08. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 144 from L to S is predicted to be TOLERATED with a score of 0.05. Median sequence conservation: 3.05 Sequences represented at this position:229

Substitution at pos 145 from A to T is predicted to AFFECT PROTEIN FUNCTION with a score of 0.02. Median sequence conservation: 3.01 Sequences represented at this position:249

Substitution at pos 145 from A to G is predicted to be TOLERATED with a score of 0.16. Median sequence conservation: 3.05 Sequences represented at this position:229

Substitution at pos 146 from C to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:229

 Substitution at pos 147 from G to D is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:248

Substitution at pos 147 from G to R is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.05 Sequences represented at this position:229

Substitution at pos 148 from V to G is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.01 Sequences represented at this position:247

Substitution at pos 148 from V to I is predicted to be TOLERATED with a score of 0.40. Median sequence conservation: 3.05 Sequences represented at this position:226

Substitution at pos 149 from I to T is predicted to AFFECT PROTEIN FUNCTION with a score of 0.01. Median sequence conservation: 3.05 Sequences represented at this position:225

Substitution at pos 151 from I to T is predicted to AFFECT PROTEIN FUNCTION with a score of 0.02. Median sequence conservation: 3.02 Sequences represented at this position:243

Substitution at pos 151 from I to S is predicted to AFFECT PROTEIN FUNCTION with a score of 0.00. Median sequence conservation: 3.02 Sequences represented at this position:243