PolyPhen-2 prediction of functional effects of human nsSNPs

PolyPhen-2 report for P00441 H49R

Query

Protein Acc Position AA1 AA2 Description
P00441 49 H R RecName: Full=Superoxide dismutase [Cu-Zn]; EC=1.15.1.1; LENGTH: 154 AA

Results

Prediction/Confidence   PolyPhen-2 v2.0.23r349

HumDiv

This mutation is predicted to be probably damaging with a score of 0.999 (sensitivity: 0.12; specificity: 0.99)

Confidence

HumVar

Details

Multiple sequence alignment   UniProtKB/UniRef100 Release 2010_11 (02-Nov-2010)
3D Visualization   PDB/DSSP Snapshot 09-Nov-2010 (69162 Structures)