Human SOD1 non synonymous SNP analysis

 

Position

Natural variant

SNPs&GO

Polyphen2

SNAP

Pmut

Sift

PhD-SNP

nsSNP

Analyzer

Aggregation Tendency (TANGO)

 Amyloid Propensity (WALTZ)

Chaperone Binding Tendency (LIMBO)

Protein Stability (FoldX)

Structural Analisys

Natural variant

Met

1

2

3

4

Ala4Val

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Neutral

Increases

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

A4V

Ala4Thr

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

A4T

Ala4Ser

Disease

Benign

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

A4S

5

Val5Leu

Disease

Probably damaging

Neutral

Pathological

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Not afected

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

V5L

6

Cys6Gly

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Disease

Not afected

 Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

C6G

Cys6Phe

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Increases

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

C6F

Cys6Ser

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

C6S

7

Val7Glu

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Slightly reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

V7E

8

Leu8Gln

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

L8Q

Leu8Val

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

L8V

9

10

Gly10Val

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G10V

Gly10Arg

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G10R

11

12

Gly12Arg

Disease

Probably damaging

Non neutral

Pathological

Tolerated

Disease

Disease

Not afected

Not afected

Not afected

Slightly reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G12R

13

14

Val14Met

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Decreases

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

V14M

Val14Gly

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

V14G

15

16

Gly16Ala

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Increases

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G16A

Gly16Ser

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Increases

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G16S

17

18

19

Asn19Ser

Disease

Benign

Neutral

Neutral

Tolerated

Neutral

Disease

Not afected

Decreases

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

N19S

20

Phe20Cys

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

F20C

21

Glu21Lys

Disease

Benign

Non neutral

Pathological

Tolerated

Neutral

Neutral

Not afected

Not afected

Not afected

Slightly enhances

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

E21K

Glu21Gly

Disease

Probably damaging

Non neutral

Pathological

Tolerated

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

E21G

22

Gln22Leu

Disease

Benign

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Not afected

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

Q22L

Gln22Arg

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

Q22R

23

24

25

26

27

28

29

Val29Ala

Disease

Probably damaging

Non neutral

Neutral

Tolerated

Neutral

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

V29A

30

31

32

33

34

35

36

37

Gly37Arg

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G37R

38

Leu38Arg

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

L38R

Leu38Val

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

L38V

39

40

41

Gly41Ser

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G41S

Gly41Asp

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G41D

42

43

His43Arg

Disease

Probably damaging

Non neutral

Pathological

Tolerated

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

H43R

44

45

Phe45Cys

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

F45C

46

His46Arg

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

H46R

47

Val47Phe

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Slightly enhances

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

V47F

Val47Ala

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

V47A

48

His48Arg

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

H48R

His48Gln

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

H48Q

49

Glu49Lys

Disease

Benign

Non neutral

Neutral

Tolerated

Disease

Neutral

Not afected

Not afected

Not afected

Slightly reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

E49K

50

51

52

53

54

Thr54Arg

Disease

Benign

Non neutral

Pathological

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Not afected

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

T54R

55

56

57

58

59

Ser59Ile

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

S59I

60

61

Gly61Arg

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G61R

62

63

64

65

Asn65Ser

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Not afected

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

N65S

66

Pro66Ala

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Neutral

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

P66A

Pro66Ser

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

P66S

67

Leu67Arg

Disease

Benign

Non neutral

Neutral

Tolerated

Disease

Neutral

Not afected

Not afected

Not afected

Not afected

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

L67R

68

69

70

71

72

Gly72Ser

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G72S

Gly72Cys

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G72C

73

74

75

76

Asp76Val

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Slightly reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D76V

Asp76Tyr

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Not afected

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D76Y

77

78

79

80

His80Arg

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

H80R

His80Ala

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

H80A

81

82

83

84

Leu84Phe

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

L84F

Leu84Val

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

L84V

85

Gly85Arg

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G85R

Gly85Ser

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G85S

86

Asn86Ser

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

N86S

Asn86Asp

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

N86D

Asn86Lys

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Not afected

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

N86K

Asn86Ile

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Not afected

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

N86I

87

Val87Met

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Slightly reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

V87M

Val87Ala

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

V87A

88

89

Ala89Thr

Disease

Probably damaging

Non neutral

Neutral

Tolerated

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

A89T

Ala89Val

Disease

Probably damaging

Non neutral

Pathological

Tolerated

Disease

Neutral

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

A89V

90

Asp90Val

Disease

Benign

Non neutral

Pathological

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D90V

Asp90Ala

Disease

Benign

Non neutral

Pathological

Tolerated

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D90A

91

92

93

Gly93Val

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G93V

Gly93Ala

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G93A

Gly93Cys

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G93C

Gly93Arg

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G93R

Gly93Asp

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G93D

Gly93Ser

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G93S

94

95

Ala95Val

Disease

Probably damaging

Non neutral

Pathological

Tolerated

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

A95V

Ala95Thr

Disease

Probably damaging

Non neutral

Neutral

Tolerated

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

A95T

Ala95Gly

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

A95G

96

Asp96Val

Disease

Benign

Neutral

Neutral

Tolerated

Disease

Neutral

Increases

Not afected

Not afected

Not afected

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D96V

Asp96Asn

Disease

Benign

Neutral

Neutral

Tolerated

Neutral

Neutral

Not afected

Not afected

Not afected

Not afected

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D96N

97

Val97Met

Disease

Probably damaging

Non neutral

Neutral

Tolerated

Neutral

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

V97M

Val97Leu

Disease

Probably damaging

Non neutral

Pathological

Tolerated

Neutral

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

V97L

98

99

Ile99Val

Disease

Benign

Neutral

Neutral

Tolerated

Neutral

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

I99V

100

Glu100Gly

Disease

Benign

Non neutral

Pathological

Tolerated

Disease

Neutral

Not afected

Not afected

Not afected

Slightly reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

E100G

Glu100Lys

Disease

Benign

Non neutral

Neutral

Tolerated

Neutral

Neutral

Not afected

Not afected

Not afected

Not afected

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

E100K

101

Asp101Gly

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D101G

Asp101Asn

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D101N

Asp101Tyr

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D101Y

Asp101His

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D101H

102

103

104

Ile104Phe

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

I104F

105

Ser105Leu

Disease

Probably damaging

Non neutral

Neutral

Tolerated

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

S105L

106

Leu106Val

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

L106V

Leu106Phe

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

L106F

107

108

Gly108Val

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G108V

109

110

111

Cys111Tyr

Disease

Benign

Non neutral

Pathological

Affect protein function

Disease

Unknown

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

C111Y

112

Ile112Thr

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

I112T

Ile112Met

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

I112M

113

Ile113Thr

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

I113T

Ile113Phe

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

I113F

114

Gly114Ala

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G114A

115

Arg115Gly

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Increases

Not afected

Not afected

Slightly reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

R115G

116

117

Leu117Val

Disease

Benign

Neutral

Neutral

Tolerated

Neutral

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

L117V

118

Val118Leu

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

V118L

119

120

121

122

123

124

Asp124Val

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D124V

Asp124Gly

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D124G

125

Asp125His

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Not afected

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

D125H

126

Leu126Ser

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

L126S

Leu126STOP

127

Gly127Arg

Disease

Probably damaging

Neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G127R

128

129

130

131

132

133

Glu133Val

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Unknown

Not afected

Not afected

Not afected

Slightly reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

E133V

134

Ser134Asn

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease

Neutral

Not afected

Not afected

 Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

S134N

135

136

137

Thr137Arg

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Neutral

Not afected

Not afected

Not afected

Slightlys enhances

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

T137R

138

Gly138Glu

Disease

Probably damaging

Non neutral

Pathological

Affect protein function

Disease

Disease

Not afected

Not afected

Not afected

Severely reduces

Descrição: Descrição: C:\Users\Joelma\Documents\2012-1\SOD-Lorenna\Site\sod1\snp\link.jpg

G138E

139

Asn139His

Disease

Probably damaging

Non neutral

Neutral

Affect protein function

Disease